Mpox infection in animals: a systematic review and meta-analysis

Mpox infection in animals: a systematic review and meta-analysis

martes, abril 23, 2024

ABSTRACT

Mpox is a zoonotic disease that became epidemic in multiple countries in 2022. There is a lack of published systematic reviews on natural animal infection due to Mpox. We performed a systematic literature review with meta-analysis to assess animal Mpox prevalence. We performed a random-effects model meta-analysis to calculate the pooled prevalence and 95% confidence interval (95%CI) for prevalence studies. After the screening, 15 reports were selected for full-text assessment and included in qualitative and quantitative analyses. Ten reports assessed Mpox infection by molecular or serological tests (n=2,680), yielding a pooled prevalence of 16.0% (95%CI: 3.0–29.0%) for non-human primates; 8.0% (95%CI: 4.0–12.0%) for rodents and 1.0% (95%CI: 0.0–3.0%) for shrews. Further studies in other animals are required to define the extent and importance of natural infection due to Mpox. These findings have implications for public human and animal health. OneHealth approach is critical for prevention and control.

NOMBRE DE LA REVISTA

Journal of Infection and Public Health

BASE DE DATOS A LA CUAL PERTENECE

Scopus, ClinicalKey, Science Citation Index Expanded, DOAJ, PubMed/Medline, Embase

TIPO DE MANUSCRITO

Revisión sistemática y meta-análisis

IDIOMA

Inglés 

AUTORES DE LA SOCIEDAD 

Enrique A. Hernandez-Bustamante

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Short-Term Adverse Effects of the Fourth Dose of Vaccination against COVID-19 in Adults over 40 Years of Age

Short-Term Adverse Effects of the Fourth Dose of Vaccination against COVID-19 in Adults over 40 Years of Age

miércoles, abril 10, 2024

ABSTRACT

Booster vaccines are a strategy to mitigate the conditions in the health, social, and economic fields that the COVID-19 pandemic has brought. A series of adverse effects have been observed since the first vaccination. The present investigation aims to describe the short-term adverse effects of the fourth dose against COVID-19 in adults older than 40 from a region of Peru. The study population was over 40 years of age at the COVID-19 vaccination center in Trujillo, Peru. A 21-day follow-up was conducted from vaccination with the fourth dose, considering sex, age, body mass index, comorbidities, history of COVID-19 infection, vaccination schedule, and simultaneous vaccination against influenza as variables of interest. Multinomial logistic regression with robust variance was used to estimate the risk ratio (RR). In total, 411 people were recruited, and it was found that 86.9% of the participants presented adverse effects after injection with the fourth dose of the vaccine against COVID-19. Pain at the injection site was the most reported symptom after 3 days. Assessment of adverse effects after 3 days found that age ≥ 60 years was associated with a lower likelihood of adverse effects compared to those younger than 60 years (RRc: 0.32; 95% CI: 0.0.18–0.59), males compared to females were associated with a lower likelihood of adverse effects (RRc: 0.54; 95% CI 0.30–0.98), being overweight (RRc: 2.34; 95% CI: 1.12–4.89), and last vaccine with Pfizer-BioN-Tech (RRc: 0.42; 95% CI: 0.18–0.96). Associated adverse effects are mild to moderate. Injection site pain and general malaise are the most frequent adverse effects.

NOMBRE DE LA REVISTA

Vaccines

BASE DE DATOS A LA CUAL PERTENECE

Scopus, SCIE (Web of Science), PubMed, PMC, Embase, CAPlus/SciFinder

TIPO DE MANUSCRITO

Estudio observacional analítico de cohorte prospectivo

IDIOMA

Inglés 

AUTORES DE LA SOCIEDAD 

Jussara Malo-Castillo, Harold Jiménez-Álvarez, Victor Ludeña-Meléndez, Solange Sarasvati Mayor Castro, Paula Ishikawa-Arias

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Disgerminoma puro de ovario gigante en paciente joven de 19 años

Disgerminoma puro de ovario gigante en paciente joven de 19 años

miércoles, abril 03, 2024

RESUMEN

El disgerminoma de ovario es una neoplasia muy infrecuente. Se presenta mayormente en mujeres jóvenes con manifestaciones clínicas inespecíficas, aunque pueden señalar dolor abdominal, sensación de masa y alteraciones menstruales. Se comunica el caso de una paciente joven de 19 años multípara con sensación de masa intraabdominal, de crecimiento progresivo y asociado a dolor de tipo opresivo. En el examen tomográfico se encontró una masa anexial dependiente de ovario, por lo que se le practicó una anexectomía derecha y biopsia por congelación más estadiaje. La evaluación macroscópica evidenció una tumoración de 25 x 20 x 13 cm, que pesaba 5,760 gramos. Mediante evaluación microscópica y estudios de inmunohistoquímica se la diagnosticó como disgerminoma puro. En base al tamaño promedio y antecedentes, fue catalogada como disgerminoma gigante.

NOMBRE DE LA REVISTA

Revista Peruana de Ginecología y Obstetricia

BASE DE DATOS A LA CUAL PERTENECE

Scopus, SciELO, ESCI Web of Science, REDIB, Dialnet, MIAR, EuroPub, DOAJ, HINARI, Redalyc, IMBIOMED, Latindex, LILACS, LIPECS

TIPO DE MANUSCRITO

Reporte de caso

IDIOMA

Español, Inglés 

AUTORES DE LA SOCIEDAD 

Elkin J. Pelaes-Cruz

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Diagnostic performance of the GGT/HDL-C ratio for NAFLD in adults with obesity undergoing bariatric surgery

Diagnostic performance of the GGT/HDL-C ratio for NAFLD in adults with obesity undergoing bariatric surgery

martes, abril 02, 2024

ABSTRACT

Background Non-alcoholic fatty liver disease (NAFLD) has become the most frequent liver disease, closely related with metabolic risk factors such as obesity, insulin resistance, dyslipidemia, diabetes mellitus, and metabolic syndrome. In this context, γ-Glutamyl transpeptidase (GGT) and high-density lipoprotein cholesterol (HDL-C) have shown correlations with steatosis severity and metabolic syndrome, respectively. This positions the GGT/HDL-C ratio as a potential diagnostic indicator for NAFLD. Objective To assess the diagnostic performance of the GGT/HDL-C ratio for NAFLD in adults with obesity undergoing bariatric surgery. Methods We conducted an analytical cross-sectional study, designed as a diagnostic test evaluation. A secondary database of 249 adults with obesity was analyzed. The optimal cut-off point was ascertained using three methodologies, and five adjustment models were constructed for the total population, further stratified by sex. Results The optimal cut-off point was 20.5 U/mmol and the AUC of the ratio was 0.81 (95% CI: 0.64–0.98), with sensitivity and specificity being 82.5% and 77.8%, respectively. In the overall group with an elevated GGT/HDL-C ratio, the prevalence of NAFLD increased by 14% (PR: 1.14; 95% CI: 1.04–1.33). Specifically, women displaying this altered ratio showed a 19% increased prevalence (PR: 1.19; 95% CI: 1.07–1.42) compared to those with normal values. Conclusions The GGT/HDL-C ratio is a promising biomarker for the diagnosis of NAFLD in an adult population living with obesity.

NOMBRE DE LA REVISTA

Diabetes Research and Clinical Practice

BASE DE DATOS A LA CUAL PERTENECE

Scopus, Pubmed, Science Citation Index Expanded

TIPO DE MANUSCRITO

Artículo original

IDIOMA

Inglés 

AUTORES DE LA SOCIEDAD 

Jerry K. Benites-Meza

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